Why use our renal models ?
Express all major renal transporters and other functional properties
Available in versions modelling all pre-clinical species
Extensively validated on DDI and nephrotoxicity test compound
Kindey tissue models
aProximate™ Proximal tubule cells
aProximate™ is a validated, near physiological renal transporter model for use in drug transport and renal toxicity studies.
Glomerulus
A fully differentiated, primary podocyte cell model isolated from fresh kidney tissue for the assessment of drug-induced renal toxicity as well as glomerular permeability.
Products
Human Primary Proximal tubule cells
Services
Drug drug interactions and DDI
- Drug transporter assay with primary proximal tubule cells (species : Human, rat, mouse and dog)
- Drug interactions assay with assay with primary proximal tubule cells (species : Human, rat, mouse and dog)
- Flux and net transporter measurements assay with primary proximal tubule cells (species : Human, rat, mouse and dog)
- Measurements of intracellular drug and metabolite concentrations assay with primary proximal tubule cells (species : Human, rat, mouse and dog)
Renal toxicity
- Renal toxicity assay for drug safety evaluation with primary proximal tubule cells (species : Human, rat, mouse and dog)
- Renal toxicity assay for drug safety evaluation with primary glomerulus podocyte cells (species : Human)
Cross-species comparison
Kidney disease modelling
- Chronic kidney disease : Calcium and phosphate transporters imbalance with primary proximal tubule cells
- Metabolic diseases : Amino acid transporter impairment with primary proximal tubule cells
- Gout: Urate transporters deficiency with primary proximal tubule cells
- Focal segmental Glomerulosclerosis (FSGS) with primary glomerular podocytes
- Diabetes with primary glomerular podocytes
Newcells offering in kidney
Dr Kathryn Garner, Head of Kidney Development
Working with us
Timely service
Our ethical and secure primary tissue supply chain enables us to run studies and produce products to meet customers important and demanding timelines. We process multiple primary tissue every month meaning order-to-data response times can fit with the most demanding of customer deadlines.
Model validation
Our kidney tissue models are well-characterised and rigorously validated to ensure the generation of robust and comparable data predictive of in vivo renal physiology. Our clients also value our scientific expertise supporting the experimental design as well as the analysis and interpretation of data.
How we support our clients
By providing predictive data, we give our clients confidence in their key decision processes using our renal transporter models. Our service enables identification of cross-species differences in renal drug handling, identification of clinically relevant transporter-mediated Drug-Drug interactions and assessment of drug-induced kidney damage.
Our expertise
Our team have an in-depth knowledge of kidney physiology, cell-based models and assay development. They have designed and completed hundreds of studies on novel compounds using the unique renal models and provided interpreted data sets to customers to advance candidates into the clinic. Working under a QMS environment, the data and reports have been used to support regulatory submissions.
