Updates: Kidney - Page 2
Developing a 3D in vitro proximal tubule model for chronic toxicity studies
The kidney proximal tubule is of key interest in drug discovery. This is due to its primary role in the excretion and reabsorption of xenobiotics, such as drugs and…
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Improved in vitro renal tubular drug transport modelling to meet regulatory & development cost challenges
The proximal tubule is key due to its role in the excretion and reabsorption of many xenobiotic compounds. Due to the high costs associated with drug discovery and the…
Read updateBiologics & the kidney – importance of transport & safety assessment
Biologics represent a new modality of drug molecules which is rapidly expanding in market share and in the number of biologics gaining regulatory approval each year. Biologics are defined…
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Renal drug handling and drug-drug interactions in ADMET
The assays currently offered are based on human or animal cells transfected to express single or dual human kidney transporters on their surfaces. The major limitation is that they…
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