In vitro tissue models that mimic in vivo human physiology to improve drug discovery
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We suggest a 3 phased customised comprehensive study on our aProximate model
This step consists in quantifying the expression of the transporter of interest in the model by qPCR, immunohistochemistry and Western blot.
This study aims to validate functionality of the transporter of interest in the model by measuring and inhibiting flux of a prototypic substrate.
In this step of the study we will assess the renal transport of your compound.Click here to best define your assay of interest
We will carry out a 2 step service
We will develop a robust and validated disease model from which you can then obtain key insights into the basis of the disease and enable the rapid evaluation of new treatments in vitro.You will need to provide us with the relevant iPSCs line for our team of experts to generate and validate the retinal organoids or RPE models.The validation includes: brightfield imaging morphological characterisation and qualitative and quantitative analysis of key markers expression by fluorescent imaging and gene expression. Studies on RPE also include analysis of phagocytosis of photoreceptors, trans-epithelial resistance (TEER) measurements, growth factor secretion and protein expression analysis by flow cytometry.
Click here to choose what data you are looking to obtain from your disease model
What study are you looking to carry out on your disease model?The following studies can be run individually, or you can combine multiple. Select each individually to progress.
What study are you looking to carry out?The following studies can be run individually, or you can combine multiple. Select each individually to progress.
Step 1 of 3
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