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Newcells Biotech

P52 – Determination of aminoglycoside toxicity in human renal proximal tubule monolayers using clinical relevant biomarkers of nephrotoxicity

Colin Brown, Lyle Armstrong, Mike Nicholds, Git Nicholds Drug Metabolism and Pharmacokinetics. 2020; 35(1):S37

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Newcells Biotech

Primary human proximal tubule cell monolayers as a predictive model of renal phosphate homeostasis in heath & disease

Colin D. A. Brown. Drug Metabolism and Pharmacokinetics. 2017; 32(1): S14-S15

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Characterisation of human tubular cell monolayers as a model of proximal tubular xenobiotic handling

Colin D. A. Brown, Rachel Sayer, Amy S Windass, Iain S Haslam, Marc E De Broe, Patrick C D’Haese, Anja Verhulst Toxicology and Applied Pharmacology. 2008; 233(3): 428-438

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Freshly isolated primary human proximal tubule cells as an in vitro model for the detection of renal tubular toxicity

Freshly isolated primary human proximal tubule cells as an in vitro model for the detection of renal tubular toxicity

Piyush Bajaj, Git Chung, Keith Pye, Tomoya Yukawa, Akio Imanishi, Yuichi Takai, Colin Brown, Matthew P.Wagoner
Toxicology. 2020; 442:152535

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A storyboard of renal transport

In vitro models for accurate prediction of renal tubular xenobiotic transport in vivo

Jelle Vriend, Keith R. Pye, Colin Brown. Current Opinion in Toxicology. 2021; 25: 15-22

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Cross species comparisons

aProximate™ as a novel, predictive model of aminoglycoside-induced nephrotoxicity

Keith Pye, Git Chung, Lyle Armstrong, Mike Nicholds, Colin Brown Abstracts of the 55th Congress of the European Societies of Toxicology (EUROTOX 2019) TOXICOLOGY SCIENCE PROVIDING SOLUTIONS. Toxicol Lett. 2019;314:S167–8.

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A microscope image of a proximal tubule

Development of a novel predictive in vitro non human primate proximal tubule model for drug transporter & nephrotoxicity studies

Colin Brown Drug Metabolism and Pharmacokinetics. 2019; 34(1):S53

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Newcells Biotech

Review of pharmacokinetics & metabolism of triclopyr herbicide in mammals: Impact on safety assessments

Michael Bartels, Colin Brown, Git Chung, Melissa Chan, Claire Terry, Sean Gehen, Marco Corvaro Regulatory toxicology and pharmacology. 2020; 116:104714

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Newcells Biotech

c-Rel orchestrates energy-dependent epithelial & macrophage reprogramming in fibrosis

Nature Metabolism. 2020; 2:1350–1367

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