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Development of a novel predictive in vitro non human primate proximal tubule model for drug transporter & nephrotoxicity studies
Colin Brown Drug Metabolism and Pharmacokinetics. 2019; 34(1):S53
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Review of pharmacokinetics & metabolism of triclopyr herbicide in mammals: Impact on safety assessments
Michael Bartels, Colin Brown, Git Chung, Melissa Chan, Claire Terry, Sean Gehen, Marco Corvaro Regulatory toxicology and pharmacology. 2020; 116:104714
Find out morec-Rel orchestrates energy-dependent epithelial & macrophage reprogramming in fibrosis
Nature Metabolism. 2020; 2:1350–1367
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The aProximateâ„¢ in vitro renal proximal tubule cell model as a platform to investigate the renal uptake and nephrotoxic liability of Antisense Oligonucleotide drug molecules
An in-vitro high-content imaging assay for the study of fibroblast activation and matrix deposition
Comparison of multiple batches of human iPSC-derived retinal organoids produced at large scale
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Case Studies
View allQuantitative Fibroblast-to-Myofibroblast Transition (FMT) studies
Quantitative FMT assay with high content imaging
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In vitro evaluation of ocular toxicity and phenotypic rescue
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In vitro selection of the most relevant species to predict human
Evaluation of glomerular ADC toxicity in podocytes
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Gene therapy viral vector assessment on retinal organoids
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Gene therapy viral vector assessment on RPE cells
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