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Resources

Scientific Publications

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Cross species comparisons

aProximate™ as a novel, predictive model of aminoglycoside-induced nephrotoxicity

Keith Pye, Git Chung, Lyle Armstrong, Mike Nicholds, Colin Brown Abstracts of the 55th Congress of the European Societies of Toxicology (EUROTOX 2019) TOXICOLOGY SCIENCE PROVIDING SOLUTIONS. Toxicol Lett. 2019;314:S167–8.

A microscope image of a proximal tubule

Development of a novel predictive in vitro non human primate proximal tubule model for drug transporter & nephrotoxicity studies

Colin Brown Drug Metabolism and Pharmacokinetics. 2019; 34(1):S53

Newcells Biotech

Review of pharmacokinetics & metabolism of triclopyr herbicide in mammals: Impact on safety assessments

Michael Bartels, Colin Brown, Git Chung, Melissa Chan, Claire Terry, Sean Gehen, Marco Corvaro Regulatory toxicology and pharmacology. 2020; 116:104714

Posters

The aProximate™ in vitro renal proximal tubule cell model as a platform to investigate the renal uptake and nephrotoxic liability of Antisense Oligonucleotide drug molecules

An in-vitro high-content imaging assay for the study of fibroblast activation and matrix deposition

Comparison of multiple batches of human iPSC-derived retinal organoids produced at large scale

White Papers

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Fact Sheets

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Scientific eBooks

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Q&A with our scientists

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Videos and Webinars

Retinal Organoids as an Emerging Tool for Drug Discovery

Dr Colin Brown

The Kidney as a Therapeutic Target: Targeting Therapeutics to the Proximal Tubule

NIH/NEI 3D-ROC Sponsor Webinar

NIH/NEI 3D-ROC Sponsor Webinar

Case Studies

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Quantitative Fibroblast-to-Myofibroblast Transition (FMT) studies

Quantitative FMT assay with high content imaging

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Human Lung Fibroblasts stimulated with TGF-β for 72 hours and immunostained to detect α-SMA, as a measure of extracellular matrix production and deposition.

In vitro evaluation of ocular toxicity and phenotypic rescue

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Newcells Biotech to develop 3D retinal organoids using hiPSC derived skin cells

In vitro selection of the most relevant species to predict human renal toxicity

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A microscope image of a nephron model

Evaluation of glomerular ADC toxicity in podocytes

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Gene therapy viral vector assessment on retinal organoids

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Gene therapy viral vector assessment on RPE cells

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RPE

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