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Freshly isolated primary human proximal tubule cells as an in vitro model for the detection of renal tubular toxicity
Piyush Bajaj, Git Chung, Keith Pye, Tomoya Yukawa, Akio Imanishi, Yuichi Takai, Colin Brown, Matthew P.Wagoner
Toxicology. 2020; 442:152535
In vitro models for accurate prediction of renal tubular xenobiotic transport in vivo
Jelle Vriend, Keith R. Pye, Colin Brown. Current Opinion in Toxicology. 2021; 25: 15-22
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aProximateâ„¢ as a novel, predictive model of aminoglycoside-induced nephrotoxicity
Keith Pye, Git Chung, Lyle Armstrong, Mike Nicholds, Colin Brown Abstracts of the 55th Congress of the European Societies of Toxicology (EUROTOX 2019) TOXICOLOGY SCIENCE PROVIDING SOLUTIONS. Toxicol Lett. 2019;314:S167–8.
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Development of highly-differentiated human primary proximal tubule MPS model (aProximate MPSâ„¢ Flow)
The aProximateâ„¢ in vitro renal proximal tubule cell model as a platform to investigate the renal uptake and nephrotoxic liability of Antisense Oligonucleotide drug molecules
Developing a Comprehensive Biomarker Package for Detecting Drug-Induced Injury in Podocytes
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Videos and Webinars
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Reducing compound attrition by predicting renal tubular toxicity with in vitro PTEC models
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Improved phenotype of human proximal tubule epithelial cells in a 3D microfluidic model
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Predictive in vitro primary proximal tubule models for understanding nephrotoxicity in drug development programs
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View allQuantitative Fibroblast-to-Myofibroblast Transition (FMT) studies
Quantitative FMT assay with high content imaging
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In vitro evaluation of ocular toxicity and phenotypic rescue
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In vitro selection of the most relevant species to predict human
Evaluation of glomerular ADC toxicity in podocytes
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Gene therapy viral vector assessment on retinal organoids
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Gene therapy viral vector assessment on RPE cells
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