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Scientific Publications

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Comparison of the Impact of VRP-034 and Polymyxin B upon markers of Kidney Injury in Human Proximal Tubule Monolayers In Vitro

Keith Pye, Elena Tasinato, Siannah Shuttleworth, Claire Devlin and Colin Brown

Development of a Highly Differentiated Human Primary Proximal Tubule MPS Model (aProximate MPS Flow)

Francesca Pisapia, Donovan O'Brien, Elena Tasinato, Kathryn L. Garner and Colin D.A. Brown

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Significance of OAT2 and OCT2 in creatinine clearance: Mechanistic evaluation using freshly-prepared human primary renal proximal tubule cells

Sumathy Mathialagan, Git Chung, Keith Pye, A. David Rodrigues, Manthena V. S. Varma and Colin Brown

Posters

Utilization of high – content imaging for the study of lung fibrosis

High content imaging (HCI) assays enable the study of the fibrotic processes: fibroblast – to – myofibroblast transition (FMT) and epithelial – to – mesenchymal transition (EMT)

The aProximateTM model for renal drug safety/efficacy and transporter studies

White Papers

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Newcells Biotech

Use of the aProximate Proximal Tubule Cell model for the evaluation of safety and renal accumulation of radioconjugates and large molecules

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Fact Sheets

Ciliary beat frequency analysis assay for lung small airway epithelium cells (SAEC)

iPSC-derived Retinal Pigment Epithelium (RPE)

iPSC-derived Retinal Organoids (RO)

Scientific eBooks

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Q&A with our scientists

Dr Fiona Leslie

Meet the scientists: Dr Fiona Leslie, the scientist behind the development of the advanced FMT assay

Dr Colin Brown face inside cells

The inside story of the development of Newcells’ MPS flow model: Scientific chat with Dr Colin Brown

Lady smiling

Q&A with Dr Carolina Gandara, Head of retina assay development

Videos and Webinars

Dr Mike Nicholds – How Newcells works with Clients

Dr Mike Nicholds – Newcells Offerings

Dr Kathryn Garner – Newcells Career Video

Case Studies

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Quantitative Fibroblast-to-Myofibroblast Transition (FMT) studies

Quantitative FMT assay with high content imaging

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Human Lung Fibroblasts stimulated with TGF-β for 72 hours and immunostained to detect α-SMA, as a measure of extracellular matrix production and deposition.

In vitro evaluation of ocular toxicity and phenotypic rescue

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Newcells Biotech to develop 3D retinal organoids using hiPSC derived skin cells

In vitro selection of the most relevant species to predict human renal toxicity

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A microscope image of a nephron model

Evaluation of glomerular ADC toxicity in podocytes

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Gene therapy viral vector assessment on retinal organoids

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Gene therapy viral vector assessment on RPE cells

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RPE

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