Investigate renal drug transport modalities and drug interactions in vitro
aProximate™ PTCs retain high expression of the relevant transporter involved in drug handling so it is ideal for drug transporter and drug interaction studies. Given the presence of Megalin and cubilin, two key uptake transporters for large molecules, the model is particularly insightful to predict the transport or retention of antibody drug conjugates (ADCs), antibiotics, anti-sense oligonucleotides (ASO) and radiolabelled conjugate in the proximal tubule. Transporters play a major role in the uptake and efflux of drugs across cellular membranes. Drug interactions with transporter proteins are common and can act either as substrates and/or inhibitors, a role which is best be identified during the early-stages of drug development to define the absorption, distribution, metabolism and excretion (ADME) profile. Using our scientific expertise, Newcells provides transporter assays using the aProximate™ model to answer your specific requirements and understand potential drug drug interactions of both small and large mocules.
Service outputs
- Flux Assay: Apical to Basal (Jab) and Basal to Apical (Jba) flux
- Net transport measurements
- Uptake assays : measurement of intracellular drug and metabolite concentrations
- Identification of transporter-mediated drug interactions
- High content imaging data
